Ion chromatography (IC) is a chromatography technique used to separate and analyze ions such as anions and cations in aqueous solutions.
The ions in the sample interact with the stationary phase in the column and are separated by being carried at different speeds by the mobile phase. The separated ions are usually detected by a conductivity detector.
Ion Chromatography studies are carried out to determine ion impurities in pharmaceutical formulations.
Ion Chromatography Types
- Anion Chromatography: Used for the analysis of anions such as NO₃⁻ (nitrate), Cl⁻ (chloride), SO₄²⁻ (sulfate).
- Cation Chromatography: Used in the analysis of cations such as Na⁺ (sodium), Ca²⁺ (calcium), Mg²⁺ (magnesium).